Water deeply but infrequently, allowing the soil to dry out between waterings to prevent root rot. Train vines onto a trellis for support, and prune excess growth to encourage fruiting. Dragon fruit is relatively pest-resistant but can be affected by aphids, mealybugs, and fungal infections, which can be controlled with neem oil or fungicides.

Dragon fruit seeds can be extracted from ripe fruit, washed, and dried for 24 hours before planting. Sow seeds in a well-draining cactus mix, lightly covering them with soil, and keep them moist in a warm, bright location (70–85°F or 21–29°C). Germination typically takes 1–4 weeks, and seedlings can be transplanted once they develop a few sets of leaves.

Dragon fruit, a climbing cactus, requires well-draining, sandy soil with a pH of 6.0–7.0 and full sun exposure. When planting in a container, choose a pot at least 15–20 gallons in size with drainage holes. If planting outdoors, provide a sturdy trellis or post to support its climbing growth, spacing plants at least 3–5 feet apart.

Dragon fruit benefits from a balanced cactus fertilizer (10-10-10) every month during the growing season and reduced feeding in winter. Adding compost or organic matter improves soil nutrients, and a potassium-rich fertilizer can enhance flowering and fruiting.

Being a tropical plant, dragon fruit is sensitive to cold temperatures below 40°F (4°C). If growing in colder climates, move potted plants indoors or cover outdoor plants with frost blankets. In winter, reduce watering to prevent root rot while the plant is dormant.

Dragon fruit takes 6–12 months to mature from cuttings and 5–7 years from seeds. Fruits are ready to harvest when they turn bright pink or red and slightly soften. To encourage better fruit production, prune dead or overcrowded stems after harvest, allowing more energy for new growth.